Halogen–magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids

F Kopp, S Wunderlich, P Knochel

Index: Kopp, Felix; Wunderlich, Stefan; Knochel, Paul Chemical Communications, 2007 , # 20 p. 2075 - 2077

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Citation Number: 27

Abstract

The magnesiation of halogenated aromatic and heteroaromatic carboxylic acids is accomplished by their treatment with MeMgCl in the presence of LiCl and subsequent reaction with i-PrMgCl· LiCl; the resulting double-magnesiated species react with a variety of electrophiles in up to 97% yield.