Synthesis, anti-inflammatory, analgaesic and anti-amoebic activity evaluation of some pyrimidobenzimidazole and pyrimidopyridoimidazole derivatives

SM Sondhi, M Johar, R Shukla, R Raghubir…

Index: Sondhi, Sham M.; Johar, Monika; Shukla, Rakesh; Raghubir, Ram; Bharti, Neelam; Azam, Amir Australian Journal of Chemistry, 2001 , vol. 54, # 7 p. 461 - 467

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Citation Number: 19

Abstract

Abstract o-Phenylenediamine, 4-nitro-1, 2-phenylenediamine, 3, 4-diaminobenzophenone, 3, 4-diaminotoluene, 4, 5-dimethylphenylenediamine and 3, 4-diaminobenzoic acid (1a–f) react with 4-isothiocyanatobutan-2-one to give the pyrimidobenzimidazole derivatives (2a–f) respectively. Condensation of 4-nitro-1, 2-phenylenediamine with 4-isothiocyanatobutan-2- one at room temperature gave the thiourea derivative (3). o-Nitroaniline, on condensation ...