Tetrahedron letters

Hydride-promoted demethylation of methyl phenyl ethers

G Majetich, Y Zhang, K Wheless

Index: Majetich, George; Zhang, Yong; Wheless, Karen Tetrahedron Letters, 1994 , vol. 35, # 47 p. 8727 - 8730

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Citation Number: 32

Abstract

Abstract Solutions of L-Selectride or SuperHydride in refluxing THF efficiently deprotect methyl phenyl ethers. L-Selectride is the more effective reagent, while electron-poor arenes work best. Unlike other hydride sources, these reagents permit ether cleavage without the reduction of aryl halides.

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