Tetrahedron Letters

Microwave-assisted N-Boc deprotection under mild basic conditions using K 3 PO 4· H 2 O in MeOH

SR Dandepally, AL Williams

Index: Dandepally, Srinivasa Reddy; Williams, Alfred L. Tetrahedron Letters, 2009 , vol. 50, # 9 p. 1071 - 1074

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Citation Number: 21

Abstract

The protection of amines with tert-butyloxycarbonyl (Boc) group is a widely used reaction in organic synthesis because of its inertness toward catalytic hydrogenolysis and resistance toward hydrolysis under most basic conditions and nucleophilic reagents. 1 N-Boc deprotection is generally achieved under mild acidic conditions 1 such as trifluoroacetic acid (TFA), either neat or in combination with CH 2 Cl 2, HCl in EtOAc, H 2 SO 4 in tBuOAc, pTSA, methanesulfonic acid in ...

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