(Aryloxy) aryl semicarbazones and related compounds: a novel class of anticonvulsant agents possessing high activity in the maximal electroshock screen

…, U Pugazhenthi, T Lechler, JP Stables

Index: Dimmock, Jonathan R.; Puthucode, Ramanan N.; Smith, Jennifer M.; Hetherington, Mark; Quail, J. Wilson; Pugazhenthi, Uma; Lechler, Terry; Stables, James P. Journal of Medicinal Chemistry, 1996 , vol. 39, # 20 p. 3984 - 3997

Full Text: HTML

Citation Number: 166

Abstract

A number of (aryloxy) aryl semicarbazones and related compounds were synthesized and evaluated for anticonvulsant activities. After intraperitoneal injection to mice, the semicarbazones were examined in the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ), and neurotoxicity (NT) screens. The results indicated that greater protection was obtained in the MES test than the scPTZ screen. Quantitation of ...

Related Articles:

Ligand-free copper-catalyzed O-arylation of nitroarenes with phenols

[Chen, Jiuxi; Wang, Xingyong; Zheng, Xingwang; Ding, Jinchang; Liu, Miaochang; Wu, Huayue Tetrahedron, 2012 , vol. 68, # 43 p. 8905 - 8907]

Ligand-free catalytic system for the synthesis of diarylethers over Cu 2 O/Cu-CNTs as heterogeneous reusable catalyst

[Zhang, Ying-Peng; Jiao, Ya-Cong; Yang, Yun-Shang; Li, Chun-Lei Tetrahedron Letters, 2013 , vol. 54, # 48 p. 6494 - 6497]

Palladium-Catalyzed Decarboxylative Coupling of Isatoic Anhydrides with Arylboronic Acids

[Zheng, Xingwang; Ding, Jinchang; Chen, Jiuxi; Gao, Wenxiao; Liu, Miaochang; Wu, Huayue Organic Letters, 2011 , vol. 13, # 7 p. 1726 - 1729]

A general and efficient protocol for the synthesis of biaryl ethers from aryl silyl ethers using Cs2CO3

[Cui, Sun-Liang; Jiang, Zhi-Yong; Wang, Yan-Guang Synlett, 2004 , # 10 p. 1829 - 1831]

Synthesis of l, l-isodityrosine

[Boger, Dale L.; Yohannes, Daniel Tetrahedron Letters, 1989 , vol. 30, # 16 p. 2053 - 2056]

More Articles...