Rapid and Efficient Microwave??Assisted Synthesis of N??Carbamoyl??L??amino Acids

G Verardo, P Geatti, P Strazzolini

Index: Verardo, Giancarlo; Geatti, Paola; Strazzolini, Paolo Synthetic Communications, 2007 , vol. 37, # 11 p. 1833 - 1844

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Citation Number: 5

Abstract

Abstract A rapid and efficient method for the synthesis of N??carbamoyl??l??amino acids is reported. The procedure, involving the reaction between urea and α??amino acids sodium salts, was performed under microwave conditions using an unmodified domestic microwave oven. A careful study of the operative conditions indicated proline (1d) as the less reactive substrate and phenylglycine (1e) as the more reactive one among all the α??amino acids ...