A new class of anti-thrombosis hexahydropyrazino-[1′, 2′: 1, 6] pyrido-[3, 4-b]-indole-1, 4-dions: Design, synthesis, logK determination, and QSAR analysis

…, WX Wang, M Zhao, C Wang, Z Zhang, S Peng

Index: Liu, Jiawang; Wu, Guofeng; Cui, Guohui; Wang, Wei-Xuan; Zhao, Ming; Wang, Chao; Zhang, Ziding; Peng, Shiqi Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 17 p. 5672 - 5693

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Citation Number: 27

Abstract

Based on the fact that the cyclization of N-[(3S)]-1, 2, 3, 4-tetrahydro-β-carboline-3-carboxyl]- l-lysine in both of acetic acid aqueous (5%) and rat plasma gave the same product and the hypothesis that the cyclization product is antithrombotic active, we report the synthesis, in vitro anti-aggregation, and in vivo anti-thrombosis activity of 20 hexahydropyrazino [1′, 2′: 1, 6] pyrido [3, 4-b] indole-1, 4-dions (5a–t) as potential anti-thrombosis agents in this ...

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