Straightforward synthesis of chiral silylated amino acids through hydrosilylation

D Marchand, J Martinez…

Index: Marchand, Damien; Martinez, Jean; Cavelier, Florine European Journal of Organic Chemistry, 2008 , # 18 p. 3107 - 3112

Full Text: HTML

Citation Number: 11

Abstract

Abstract A method using hydrosilylation of unsaturated amino acids was developed and optimised to obtain silylated amino acids. The platinum (Bu 4 N) 2 PtCl 6 complex was identified as the best catalyst, and the procedure tolerated different unsaturated substrates, silane reagents and protecting groups. Seven silicon-containing α-amino acids were prepared in an enantiomerically pure form under mild conditions in good yields with ...

Related Articles:

Chemoenzymatic synthesis of the four diastereoisomers of 4-hydroxypipecolic acid from N-acetyl-(R, S)-allylglycine: chiral scaffolds for drug discovery

[Lloyd, Richard C.; Smith, Mark E. B.; Brick, Dean; Taylor, Stephen J. C.; Chaplin, David A.; McCague, Raymond Organic Process Research and Development, 2002 , vol. 6, # 6 p. 762 - 766]

Synthesis and evaluation of novel substrates and inhibitors of N-succinyl-LL-diaminopimelate aminotransferase (DAP-AT) from Escherichia coli

[Journal of the American Chemical Society, , vol. 118, # 32 p. 7449 - 7460]

Conversion of serine. beta.-lactones to chiral. alpha.-amino acids by copper-containing organolithium and organomagnesium reagents

[Journal of the American Chemical Society, , vol. 109, # 15 p. 4649 - 4659]

Use of hydrolases for the synthesis of cyclic amino acids

[Lloyd, Richard C.; Lloyd, Michael C.; Smith, Mark E. B.; Holt, Karen E.; Swift, Jonathan P.; Keene, Philip A.; Taylor, Stephen J. C.; McCague, Raymond Tetrahedron, 2004 , vol. 60, # 3 p. 717 - 728]

Use of hydrolases for the synthesis of cyclic amino acids

[Tetrahedron, , vol. 60, # 3 p. 717 - 728]

More Articles...