New methods in peptide synthesis. I. Tritylsulfenyl and o-nitrophenylsulfenyl groups as N-protecting groups

L Zervas, D Borovas, E Gazis

Index: Zervas,L. et al. Journal of the American Chemical Society, 1963 , vol. 85, p. 3660 - 3666

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Citation Number: 229

Abstract

S-Tritylamino acid p-nitrophenyl esters, with the exception of the glycine derivative, do not couple with amino acid esters. On the other hand, K-tritylsulfenyl (TRS) or No- nitrophenylsulfenyl (NPS) amino acid p-nitrophenyl esters show no steric hindrance and have been used to synthesize N-protected dipeptide esters. The So-nitrophenylsulfenyl derivatives of L-amino acids themselves have also been prepared and isolated in the pure ...