Journal of medicinal chemistry

Synthesis and biological evaluation of 4-purinylpyrrolidine nucleosides

ML Peterson, R Vince

Index: Peterson, Mark L.; Vince, Robert Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2787 - 2797

Full Text: HTML

Citation Number: 94

Abstract

The synthesis of several novel carbocyclic purine nucleosides that incorporate a nitrogen in place of carbon 3 of the cyclopentyl moiety are described. These analogues are all derived from the key stereochemically defined intermediate N-(tert-butoxycarbonyl)-0-[(4metho~ henyl) dipheny~ ethyl]-t~~-4-hy~ ox~~ prolinol (19), which was accessible in 61.1% overall yield for a five-step sequence starting from cis-4hydroxy-~-proline. The heterocyclic bases, ...

Related Articles:

Transition-metal-catalyzed asymmetric organic synthesis via polymer-attached optically active phosphine ligands. 5. Preparation of amino acids in high optical yield …

[Baker, Gregory L.; Fritschel, Scott J.; Stille, John R.; Stille, John K. Journal of Organic Chemistry, 1981 , vol. 46, # 14 p. 2954 - 2960]

Asymmetric hydrogenations for the synthesis of Boc-protected 4-alkylprolinols and prolines

[Journal of Organic Chemistry, , vol. 68, # 10 p. 3923 - 3931]

Asymmetric hydrogenations for the synthesis of Boc-protected 4-alkylprolinols and prolines

[Journal of Organic Chemistry, , vol. 68, # 10 p. 3923 - 3931]

Transition-metal-catalyzed asymmetric organic synthesis via polymer-attached optically active phosphine ligands. 5. Preparation of amino acids in high optical yield …

[Journal of Organic Chemistry, , vol. 46, # 14 p. 2954 - 2960]

Concise stereoselective synthesis of (2 S, 4 R)-4-hydroxyproline from (S)-O-benzylglycidol a novel cyclization

[Journal of the Chemical Society, Chemical Communications, , # 23 p. 1527 - 1528]

More Articles...