N-Alkylation of isatins utilizing KF/alumina

…, HM Abdallah, C Jordan, K Knisley, DM Ketcha

Index: Clay, Charles M.; Abdallah, Hagar M.; Jordan, Carly; Knisley, Kyle; Ketcha, Daniel M. Arkivoc, 2012 , vol. 2012, # 6 p. 317 - 325

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Citation Number: 5

Abstract

Abstract The N-alkylation of isatins by a variety of alkyl halides and one acrylate has been demonstrated utilizing KF/Al2O3 in acetonitrile (ACN) under microwave-irradiation (180 o C) or thermally at reflux. Keywords: Isatin, N-alkylation, microwave, KF/Al2O3, conjugate addition