A highly active catalyst for palladium-catalyzed cross-coupling reactions: room-temperature Suzuki couplings and amination of unactivated aryl chlorides

DW Old, JP Wolfe, SL Buchwald

Index: Old; Wolfe; Buchwald Journal of the American Chemical Society, 1998 , vol. 120, # 37 p. 9722 - 9723

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Citation Number: 950

Abstract

Palladium-catalyzed CN bond-forming reactions have evolved into a versatile and efficient synthetic transformation. 1 However, the lack of a general palladium-based catalyst for aryl chloride substitution reactions, 2, 3 as well as the elevated reaction temperatures often required, prompted us to search for new, more active ligands.

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