Quinolone antibacterials. 1. 7??(2??substituted??4??thiazolyl and thiazolidinyl) quinolones

…, A Haemers, D Vanden Berghe…

Index: Zhang; Haemers; Vanden Berghe; Pattyn; Bollaert; Levshin Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 3 p. 673 - 683

Full Text: HTML

Citation Number: 20

Abstract

Abstract A series of 7-(2-substituted-4-thiazolyl and thiazolidinyl)-1-ethyl-1, 4-dihydro-4- oxoquinoline-3-carboxylic acids and their 6-fluoro analogues were synthesized. The Hantzsch method was used for the preparation of the thiazolylquinolones. The thiazolidinylquinolones were synthesized by quaternization of the corresponding thiazolyl analogues, followed by reduction of the obtained thiazolium salts with sodium borohydride ...