The Synthesis of Some Peptides Related to the Active Site of Enzymes

T Hayakawa, K Harada, SW Fox

Index: Hayakawa; Harada; Fox Bulletin of the Chemical Society of Japan, 1966 , vol. 39, # 2 p. 391 - 395

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Citation Number: 13

Abstract

The sequences, α-aspartyl-L-serylglycine and α-glutamyl-L-serylglycine, appear in the “active site” of many esteratic enzymes. The free tripeptides were synthesized in this study. In order to avoid difficulties encountered in more conventional synthetic routes, N- carbobenzoxy-L-aspartyl (β-benzyl ester)-O-benzyl-L-serylglycine dibenzyl ester and N- carbobenzoxy-L-glutamyl (γ-benzyl ester)-O-benzyl-L-serylglycine dibenzyl ester were ...

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