Tetrahedron

Benzyl chloroformate (CbzCl) synthesis using carbon monoxide as a carbonyl source

T Mizuno, J Takahashi, A Ogawa

Index: Mizuno, Takumi; Takahashi, Junko; Ogawa, Akiya Tetrahedron, 2002 , vol. 58, # 50 p. 10011 - 10015

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Citation Number: 9

Abstract

A novel non-phosgene synthetic method for benzyl chloroformate (CbzCl) was established. S-Methyl O-benzyl carbonothioates were prepared by the carbonylation of benzyl alcohols with carbon monoxide and sulfur (or carbonyl sulfide) in the presence of DBU (1, 8- diazabicyclo [5.4. 0] undec-7-ene) followed by esterification using methyl iodide in good yields. Then, CbzCl derivatives were successfully synthesized by the chlorination of S- ...