Solution-Phase Peptide Synthesis; Synthesis of'North-Western'and'South Eastern'Fragments of the Antifungal Cyclodepsipeptide Petriellin A

…, RTC Brownlee, AB Hughes

Index: Aurelio, Luigi; Brownlee, Robert T. C.; Hughes, Andrew B. Australian Journal of Chemistry, 2008 , vol. 61, # 8 p. 615 - 629

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Abstract

We have an ongoing interest in the chemistry of modified amino acids, in particular N-methyl α-amino acids [1–5] and β-amino acids.[6–9] Methodological developments in this area are continuing. In the next phase of our project, we are seeking to apply N-methyl amino acids in the synthesis of target peptides including some of the growing number of naturally occurring cyclic depsipeptides found to have antifungal activity. Accordingly, our attention was ...