Biomimetic reductive amination under the continuous-flow reaction conditions

VA Soloshonok, HT Catt, T Ono

Index: Soloshonok, Vadim A.; Catt, Hector T.; Ono, Taizo Journal of Fluorine Chemistry, 2010 , vol. 131, # 2 p. 261 - 265

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Citation Number: 13

Abstract

This study present a full account of continuous-flow reaction conditions for biomimetic reductive amination of fluorinated carbonyl compounds to corresponding amines and amino acids of biomedical importance. We demonstrate that simple silica-adsorbed DBU can be used as efficient catalysts for on-column 1, 3-proton shift reaction, a key transformation in the biomimetic reductive amination process. This new on-column process features ...