Organic letters

Enantioselective Synthesis of 2, 3-Disubstituted Indanones via Pd-Catalyzed Intramolecular Asymmetric Allylic Alkylation of Ketones

XH Li, BH Zheng, CH Ding, XL Hou

Index: Li, Xiao-Hui; Zheng, Bao-Hui; Ding, Chang-Hua; Hou, Xue-Long Organic Letters, 2013 , vol. 15, # 23 p. 6086 - 6089

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Citation Number: 13

Abstract

A Pd-catalyzed intramolecular asymmetric allylic alkylation (AAA) reaction with “hard” carbanions has been developed for the first time, affording 2, 3-disubstituted indanones with high diastereo-and enantioselectivities. The transformation of these products into other core structures of natural products has been demonstrated.