An alternative synthetic process of p-acetaminobenzenesulfonyl chloride through combined chlorosulfonation by HClSO3 and PCl5

…, Z Luo, S Zhao, D Huang, J Zhang, L Dong, G Wang

Index: Tan, Shiyu; Yang, Yang; Luo, Ziping; Zhao, Shuo; Huang, Dafu; Zhang, Jun; Dong, Lichun; Wang, Gang Chemical Papers, 2011 , vol. 65, # 4 p. 510 - 518

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Abstract

Abstract p-Aminobenzene sulfonamide (sulfanilamide, SN) is the simplest and most-used sulfonamide medicine. The key step of SN production via the commonly used chlorosulfonic acid routine is the synthesis of p-acetaminobenzenesulfonyl chloride (P-ASC). A large amount of HSO 3 Cl has to be used in the traditional process, which results in serious environmental problems. In this study, an alternative chlorosulfonic acid process to ...