Helvetica Chimica Acta

The synthesis of epiboxidine and related analogues as potential pharmacological agents

I Kulu, N Ocal

Index: Kulu, Irem; Ocal, Nuket Helvetica Chimica Acta, 2011 , vol. 94, # 11 p. 2054 - 2060

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Citation Number: 10

Abstract

Abstract Methyl epiboxidine-N-carboxylate (8) was synthesized from 7 under reductive Heck conditions (Scheme 2). The C [BOND] C coupling of the new epiboxidine analog 9 with aryl and heteroaryl halides gave by hydroarylation C-aryl, N-(3-methylisoxazol-5-yl)-substituted tricyclic imides 10a–10f (Table). The [3+ 2] cycloaddition of 9 with nitrile oxides yielded the bridged dihydroisoxazole derivatives 11a–11d with potential biological activity (Scheme 4 ...