A general enzymatic method for the synthesis of natural and “unnatural” UDP-and TDP-nucleotide sugars

J Jiang, JB Biggins, JS Thorson

Index: Jiang, Jiqing; Biggins, John B.; Thorson, Jon S. Journal of the American Chemical Society, 2000 , vol. 122, # 28 p. 6803 - 6804

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Citation Number: 90

Abstract

Many bioactive metabolites possess unusual carbohydrates required for molecular recognition. 1 The glycosyltransferases which incorporate these essential ligands are known to rely almost exclusively upon UDP-and TDP-nucleotide sugars and some have demonstrated promiscuity toward the sugar donor. 2 These discoveries have led to the exploitation of the carbohydrate biosynthetic machinery to manipulate metabolite ...