Dialkylzinc-accelerated. ALPHA.-Trifluoromethylation of Carbonyl Compounds Catalyzed by Late-transition-metal Complexes

Y Tomita, Y Itoh, K Mikami

Index: Tomita, Yuichi; Itoh, Yoshimitsu; Mikami, Koichi Chemistry Letters, 2008 , vol. 37, # 10 p. 1080 - 1081

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Citation Number: 10

Abstract

Trifluoromethylation of ketone silyl enol ethers is found to be significantly accelerated by late- transition-metal catalysts and dialkylzincs to give α-trifluoromethyl ketones in good yields. Addition of dialkylzinc is the key to the high yielding α-trifluoromethylation of carbonyl compounds.