Organic letters

Synthesis of a platform to access bistramides and their analogues

M Commandeur, C Commandeur, J Cossy

Index: Commandeur, Malgorzata; Commandeur, Claude; Cossy, Janine Organic Letters, 2011 , vol. 13, # 22 p. 6018 - 6021

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Citation Number: 20

Abstract

The platform C14–C40, which can be used to prepare bistramide C and 39-oxobistramide K, was synthesized in 19 steps with an overall yield of 6.2%. Furthermore, the chemoselective reduction of the ketone at C-39 was performed giving an easy access to bistramides A, B, D, K, and L. Finally, the versatility of the synthesis of the C14–C40 fragment can allow the preparation of a large variety of stereoisomers to produce bistramide analogues.

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