Efficient Access to Enantiopure γ4??Amino Acids with Proteinogenic Side??Chains and Structural Investigation of γ4??Asn and γ4??Ser in Hybrid Peptide Helices

SV Jadhav, R Misra, SK Singh…

Index: Jadhav, Sandip V.; Misra, Rajkumar; Singh, Sumeet K.; Gopi, Hosahudya N. Chemistry - A European Journal, 2013 , vol. 19, # 48 p. 16256 - 16262

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Citation Number: 6

Abstract

Abstract Hybrid peptides composed of α-and β-amino acids have recently emerged as new class of peptide foldamers. Comparatively, γ-and hybrid γ-peptides composed of γ 4-amino acids are less studied than their β-counterparts. However, recent investigations reveal that γ 4-amino acids have a higher propensity to fold into ordered helical structures. As amino acid side-chain functional groups play a crucial role in the biological context, the objective of ...