Tetrahedron letters

An efficient synthetic route to 2-(1, 2-dithiolan-3-yl) acetic acid. Trisnorlipoic acid and amide derivatives

YS Chen, RG Lawton

Index: Chen, Yaun-Shek; Lawton, Richard G. Tetrahedron Letters, 1997 , vol. 38, # 33 p. 5785 - 5788

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Citation Number: 7

Abstract

A simple, efficient synthesis of 2-(1, 2-dithiolan-3-yl) acetic acid from Meldrum's acid, acrolein and thioacetic acid is described. The isopropyldene 2, 4-bis (acetylthio) butane-1, 1- dicarboxylate formed in the three-component, single container process, can be methanolized to the corresponding dimethyl ester and then hydrolyzed, oxidized to the disulfide and decarboxylated to 2-(1, 2-dithiolan-3-yl) acetic acid. The acid can be ...