Steroids

17α-Alkynyl-11β, 17-dihydroxyandrostane derivatives: A new class of potent glucocorticoids.

…, R Deraedt, J Benzoni, M Fortin, D Philibert

Index: Deraedt, R.; Benzoni, J.; Fortin, M.; Philibert, D. Steroids, 1981 , vol. 38, # 6 p. 651 - 666

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Citation Number: 91

Abstract

Abstract Replacement of the characteristic dihydroxyacetone side chain of corticolds by a 17α-alkynyl-17β-hydroxy moiety was investigated. It was found that, in particular, the 17α- propynyl substitution is favorable for high local anti-inflammatory activity with reduced systemic effects. Moreover, these compounds were found to be devoid of any affinity for the aldosterone receptor, and may thus be considered as pure glucocorti-coids.