Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

AL Ruchelman, HW Man, W Zhang, R Chen…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 360 - 365

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Citation Number: 18

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... A medicinal chemistry program to optimize the immunomodulatory properties of thalidomide and reduce its side-effects led to the discovery of lenalidomide (1), which is a potent immunomodulator that is ∼800 times more potent as an ...