Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor

…, E Davies, WS Miller, S Shan, KJ Valenzano…

Index: Chen, Zhengming; Davies, Ellen; Miller, Wendy S.; Shan, Shen; Valenzano, Kenneth J.; Kyle, Donald J. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5275 - 5279

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Citation Number: 8

Abstract

Small molecule mu agonists based on the 4-phenyl piperidine scaffold were designed and synthesized to further investigate the therapeutic potential of loperamide analogs. The resulting compounds show excellent agonistic activity towards the human mu receptor with interesting SAR trends within the series.

Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor

[Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 21 p. 5275 - 5279]

Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor

[Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 21 p. 5275 - 5279]

A high-yield route to synthesize the P-glycoprotein radioligand [11 C] N-desmethyl-loperamide and its parent radioligand [11 C] loperamide

[Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 19 p. 5259 - 5263]

Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor

Abstract

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