A Diels–Alder-based total synthesis of (−)-kainic acid

A Orellana, SK Pandey, S Carret…

Index: Orellana, Arturo; Pandey, Sushil K.; Carret, Sebastien; Greene, Andrew E.; Poisson, Jean-Francois Journal of Organic Chemistry, 2012 , vol. 77, # 12 p. 5286 - 5296

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Citation Number: 16

Abstract

(−)-Kainic acid (1, Figure 1) is a naturally occurring pyrrolidine with functionalized substituents at C-2, C-3, and C-4 in a trans-cis relationship. Isolated from Digenea simplex in the early 1950s,(1) it was originally used in anthelmintic and insecticide preparations. It is now recognized to be an exceptionally potent glutamate receptor agonist and has become an important tool of biologists for the study of serious neuronal disorders, such as Alzheimer's disease and ...

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