Synthesis of phthalideisoquinolines from 3-halophthamdes and 3, 4-dihydroisoquinolinium salts

…, JP Ruder, EW Hoskins, DB MacLean

Index: Slemon, Clarke E.; Hellwig, Louise C.; Ruder, Jean-Pierre; Hoskins, Eric W.; MacLean, David B. Canadian Journal of Chemistry, 1981 , vol. 59, p. 3055 - 3060

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Citation Number: 17

Abstract

Phthalideisoquinoline alkaloids have been synthesized by coupling appropriately substituted 3-halophthalides and 2-methyl-3, 4-dihydroisoquinolinium salts in the presence of Zn (Cu) couple or metallic Zn. Both erythro and threo isomers are formed in the reaction. The nmr spectra of the (±)-erythro-and (±)-threo-isocordrastines have been reinvestigated. The results, which differ from those previously reported, lead to a different conclusion ...

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