[(S)-BINAP] PdBr 2-catalyzed direct synthesis of 2, 3-disubstituted indoles via a tandem reaction between arylamines and α-diketones

…, M Ayala, L Rubio-Perez, M Amézquita-Valencia

Index: Cabrera; Sharma; Ayala; Rubio-Perez; Amezquita-Valencia, Manuel Tetrahedron Letters, 2011 , vol. 52, # 50 p. 6758 - 6762

Full Text: HTML

Citation Number: 13

Abstract

A direct PdBr2 (BINAP)-complex catalyzed method has been developed to produce 2, 3- disubstituted indoles by the reaction of arylamines with α-diketones under reductive (H2) conditions. The synthetic methodology involves a tandem reaction of three steps and all the organic intermediates were isolated and characterized, the reduction products in this sequence are chiral and present interesting enantiomeric excess. This report constitutes a ...

Related Articles:

Bismuth nitrate promoted Fischer indole synthesis: A simple and convenient approach for the synthesis of alkyl indoles

[Sudhakara, Aralihalli; Jayadevappa, Honnali; Kumar, Hosanagara N.H.; Mahadevan, Kittappa M. Letters in Organic Chemistry, 2009 , vol. 6, # 2 p. 159 - 164]

SnCl2 2H2O-An alternative to Lewis acidic ionic liquids

[Arumugam, Pandurangan; Perumal, Paramasivan T. Chemistry Letters, 2006 , vol. 35, # 6 p. 632 - 633]

N-Alkylation and N, C-Dialkylation of Amines with Alcohols in the Presence of Ruthenium Catalysts with Chelating N-Heterocyclic Carbene Ligands

[Tursky, Matyas; Lorentz-Petersen, Linda L. R.; Olsen, Lasse B.; Madsen, Robert Organic and Biomolecular Chemistry, 2010 , vol. 8, # 24 p. 5576 - 5582]

Palladium complex-catalyzed reductive N-heterocyclization of nitroarenes: novel synthesis of indole and 2H-indazole derivatives

[Akazome, Motohiro; Kondo, Teruyuki; Watanabe, Yoshihisa Journal of Organic Chemistry, 1994 , vol. 59, # 12 p. 3375 - 3380]

Vapor-phase synthesis of 3-methylindole from glycerol and aniline over zeolites-supported Cu-based catalysts

[Journal of Molecular Catalysis A: Chemical, , vol. 378, p. 238 - 245]

More Articles...