Solvent free biocatalytic synthesis of isoniazid from isonicotinamide using whole cell of Bacillus smithii strain IITR6b2

S Agarwal, M Gupta, B Choudhury

Index: Agarwal, Shilpi; Gupta, Meenu; Choudhury, Bijan Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 97, p. 67 - 73

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Citation Number: 3

Abstract

Abstract A biocatalytic route for the synthesis of isoniazid, an important first-line antitubercular drug, in aqueous system is presented. The reported bioprocess is a greener method, does not involve any hazardous reagent and takes place under mild reaction conditions. Whole cell amidase of Bacillus smithii strain IITR6b2 having acyltransferase activity was utilized for its ability to transfer acyl group of isonicotinamide to hydrazine– ...

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