Synthesis of tetrazole analogues of phosphonohydroxamic acids: An attempt to improve the inhibitory activity against the DXR

…, D Tritsch, C Grosdemange-Billiard, M Rohmer

Index: Nguyen-Trung, Anh Thu; Tritsch, Denis; Grosdemange-Billiard, Catherine; Rohmer, Michel Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1643 - 1647

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Citation Number: 9

Abstract

This work is focused on the design of new antimicrobial drugs and on the development of lipophilic inhibitors of the DXR, the second enzyme of the MEP pathway for the biosynthesis of isoprene units in most bacteria, by replacing the phosphonate group of fosmidomycin derivatives by a tetrazoyl moiety capable of multiple hydrogen bonding. The N-and C- substituted tetrazole analogues of phosphonohydroxamate inhibitors were synthesized ...

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