Highly efficient and flexible total synthesis of coelenterazine

M Keenan, K Jones, F Hibbert

Index: Keenan, Martine; Jones, Keith; Hibbert, Frank Chemical Communications, 1997 , # 3 p. 323 - 324

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Citation Number: 8

Abstract

Coelenterazine 1 found in the jellyfish Aequorea victoria was the second imidazopyrazine- based chromophore to be isolated from luminescent marine organisms. 1 Its structure was determined in 19742 and it has been synthesised using an approach developed by Kishi3 in which the fully-substituted pyrazine ring is synthesised by a condensation reaction between an a-amino nitrile and an a-nitroso ketone. In the jellyfish, coelenterazine is bound ...