Enzymic synthesis of 3-halogenoaspartic acids using β-methylaspartase: inhibition by 3-bromoaspartic acid

M Akhtar, MA Cohen, D Gani

Index: Akhtar, Mahmoud; Cohen, Mark A.; Gani, David Journal of the Chemical Society, Chemical Communications, 1986 , # 16 p. 1290 - 1291

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Citation Number: 11

Abstract

In the presence of ammonia, p-methylaspartase catalyses the conversion of halogenofumaric acids into the corresponding P-halogenoaspartic acids; one of the products, bromoaspartic acid, is an irreversible inhibitor. ... Amino acids substituted at C-3 with potential leaving groups have attracted much interest recently owing to their ability to irreversibly inactivate pyridoxal 5'-phosphate-dependent enzymes.'--3 We decided to investigate the possibility of using ...

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