Quinolone antibacterials. 2. 6??Substituted??7??(2??thiazolyl and thiazolidinyl) quinolones

…, A Haemers, D Vanden Berghe…

Index: Zhang; Haemers; Vanden Berghe; Pattyn; Bollaert; Levshin Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 3 p. 685 - 695

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Citation Number: 16

Abstract

Abstract A series of 6-substituted-1-ethyl-1, 4-dihydro-4-oxo-7-(2-thiazolyl-and thiazolidinyl) quinoline-3-carboxylic acids were synthesized. Substitution at the 6-position was H, F or Cl. The Hantzsch method was used for the preparation of the thiazolylquinolones. The thiazolidinylquinolones were synthesized by quaternization of the corresponding thiazolyl analogues, followed by reduction of the obtained thiazolium salts with sodium borohydride ...

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