The Journal of Organic Chemistry

A novel synthetic approach to pyrrolo [2, 3-d] pyrimidine antifolates

T Miwa, T Hitaka, H Akimoto

Index: Journal of Organic Chemistry, , vol. 58, # 7 p. 1696 - 1701

Full Text: HTML

Citation Number: 30

Abstract

... 1967,100,1281. (9) The Frontier orbital theory (Fleming, I. In Frontier Orbitals and Organic ChemicalReactiom; John Wiley & Sons: London, 1976; Chapter 5) and mme free radical addition reactions with enol ethen, (eg, Tsrrant, P.; Stump, E. C. J. Org. ... J. Org. Chem., Vol. 58, No. ...

Related Articles:

A new and efficient synthesis of pyrrolo [2, 3-d] pyrimidine anticancer agents: alimta (LY231514, MTA), homo-alimta, TNP-351, and some aryl 5-substituted pyrrolo [2, …

[Journal of Organic Chemistry, , vol. 68, # 26 p. 9938 - 9947]

A new and efficient synthesis of pyrrolo [2, 3-d] pyrimidine anticancer agents: alimta (LY231514, MTA), homo-alimta, TNP-351, and some aryl 5-substituted pyrrolo [2, …

[Journal of Organic Chemistry, , vol. 68, # 26 p. 9938 - 9947]

Discovery of 5-substituted pyrrolo [2, 3-d] pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4- …

[Journal of Medicinal Chemistry, , vol. 56, # 24 p. 10016 - 10032]

A simple and concise synthesis of LY231514 (MTA)

[Tetrahedron Letters, , vol. 40, # 21 p. 4023 - 4026]

A practical synthesis of multitargeted antifolate LY231514

[Organic Process Research and Development, , vol. 3, # 3 p. 184 - 188]

More Articles...