Archiv der Pharmazie

New carriers for representative peptides and peptide drugs

T Aboul??Fadl, AN El??Shorbagi

Index: Aboul-Fadl, Tarek; El-Shorbagi, Abdel-Nasser Archiv der Pharmazie, 1997 , vol. 330, # 11 p. 327 - 332

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Citation Number: 8

Abstract

Abstract 3, 5-Disubstituted tetrahydro-2H-1, 3, 5-thiadiazine-2-thione (THTT) derivatives; 4a– g were prepared and found to be a promising prodrug approach for peptide drugs. The pH profile for their degradation in aqueous buffer solutions was determined using HPLC