Organic letters

Fully automated continuous flow synthesis of highly functionalized imidazo [1, 2-a] heterocycles

A Herath, R Dahl, NDP Cosford

Index: Herath, Ananda; Dahl, Russell; Cosford, Nicholas D.P. Organic Letters, 2010 , vol. 12, # 3 p. 412 - 415

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Citation Number: 69

Abstract

The first continuous flow synthesis of imidazo [1, 2-a] pyridine-2-carboxylic acids directly from 2-aminopyridines and bromopyruvic acid has been developed, representing a significant advance over the corresponding in-flask method. The process was applied to the multistep synthesis of imidazo [1, 2-a] pyridine-2-carboxamides, including a Mur ligase inhibitor, using a two microreactor, multistep continuous flow process without isolation of ...