PO-Activated Olefination and Conversion of Aldehydes and Ketones to Higher Amines; II. Synthesis of Arylethylamines

A Heymes, I Chekroun

Index: Heymes, A.; Chekroun, I. Synthesis, 1987 , # 3 p. 245 - 249

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Citation Number: 7

Abstract

= 1 2-ClC6H4 a 4-pyridyl i 2-lhimyl 1" W10 Ch “-* b 2-thienyl e 2-() 2NC,, H,, c 2-furyl ln the above manner. aldehyde 2 (R1= H) and compound I (R2= H) afforded imine 9 (Table 1). The latter was sub sequently reacted, at ambient temperature, in eg tetrahydrofuran,'with a base eg n-butyllithium, sodium hydride or potassium r-butoxide. Anion 10 thus generated was converted as it was formed into anion lil to which aldehyde 5 was in turn added to yield Z-.: ...