Two-carbon homologation of Grignard reagents to primary amines

K Osowska-Pacewicka, A Zwierzak

Index: Osowska-Pacewicka, Krystyna; Zwierzak, Andrzej Synthesis, 1996 , # 3 p. 333 - 335

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Citation Number: 12

Abstract

Although Grignard reagents have been widely used in organic synthesis, their application for the preparation of amines is, compared to other methods, of limited value only. Several primary amines have been obtained in mo-derate to high yields by reacting 2 moles of alkylmagne-sium bromides with 1 mole of methoxyamine?'3 More recently 0- (diphenylphosphinoyl) hydroxylamine has been proposed as a reagent of choice for ...