Chlorinated thiophenes. Part 2. 1 Trihalogenated hydroxythiophenes; preparation, reactions and tautomeric properties

J Skramstad, A Lunde, H Hope, V Bjørnstad…

Index: Skramstad, Jan; Lunde, Andreas; Hope, Hakon; Bjornstad, Vidar; Froyen, Paul Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 7 p. 1453 - 1458

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Citation Number: 4

Abstract

2-Hydroxy-3, 4, 5-trichlorothiophene (4), 3-hydroxy-4-bromo-2, 5-dichlorothiophene (5) and 3-hydroxy-2, 4, 5-trichlorothiophene (6) have been synthesised. It was found that 4 exists in a carbonyl form, whereas in 5 and 6 the hydroxy forms were the major tautomers. Several derivatives of the trihalogenated hydroxythiophenes were prepared. O-Methylation was carried out with diazomethane and O-acetylation with acetyl chloride. Silylation of 4 was ...