Small molecule suppression of carbapenem resistance in NDM-1 producing Klebsiella pneumoniae

RJ Worthington, CA Bunders, CS Reed…

Index: Worthington, Roberta J.; Bunders, Cynthia A.; Reed, Catherine S.; Melander, Christian ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 5 p. 357 - 361

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Citation Number: 34

Abstract

The already considerable global public health threat of multidrug-resistant Gram-negative bacteria has become even more of a concern following the emergence of New Delhi metallo- β-lactamase (NDM-1) producing strains of Klebsiella pneumoniae and other Gram-negative bacteria. As an alternative approach to the traditional development of new bactericidal entities, we have identified a 2-aminoimidazole-derived small molecule that acts as an ...