Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp.

…, A Bolasco, R Fioravanti, P Chimenti, A Granese…

Index: Chimenti, Franco; Bizzarri, Bruna; Maccioni, Elias; Secci, Daniela; Bolasco, Adriana; Fioravanti, Rossella; Chimenti, Paola; Granese, Arianna; Carradori, Simone; Rivanera, Daniela; Lilli, Daniela; Zicari, Alessandra; Distinto, Simona Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4635 - 4640

Full Text: HTML

Citation Number: 47

Abstract

In this paper, we report on the synthesis of a novel series of 2-thiazolylhydrazone derivatives and the influence of the substituents on the thiazole ring on antifungal activity. All synthesized compounds were screened for their in vitro activities against 22 clinical isolates of Candida spp., representing six different species, compared to clotrimazole as a reference compound. Some of the tested compounds were found to possess significant antifungal ...