A versatile and efficient synthesis of substituted 1H-Indazoles

S Caron, E Vazquez

Index: Caron, Stephane; Vazquez, Enrique Synthesis, 1999 , # 4 p. 588 - 592

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Citation Number: 33

Abstract

Abstract: A facile synthesis of substituted 1H-indazole 4 from aryl mesylate 3 is described. The reaction, which proceeds through the intermediate hydrazone, was general with regard to the substituents on the arene and was applicable to several hydrazines. It was also discovered that with p-methoxyphenylhydrazine, the indazole formation was more rapid than the competitive Fischer indole synthesis. Key words: 1H-indazole, phenol, mesylate, ...