Potential noncataleptic neuroleptic agents: 2, 3-Dichloro-10-[4-(2-hydroxyethyl) piperazino]-10, 11-dihydrobenzo [b, f] thiepin

…, A Dlabač, M Valchář, M Protiva

Index: Urban; Dlabac; Valchar; Protiva Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 4 p. 992 - 1001

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Citation Number: 3

Abstract

Abstract The 6-nitro derivative V, obtained by nitration of 3, 4-dichlorobrombenzene, was transformed via the amine VI and nitrileVII to 2-bromo-4, 5-dichlorobenzoic acid (IX). Its reaction with thiophenol in 3-methyl-1-butanol in the presence of potassium carbonate and catalytic amounts of copper and cuprous iodide afforded 4, 5-dichloro-2-(phenylthio) benzoic acid (Xa) which was reduced to the alcohol XIa. The transformation to the ...