Fully automated continuous flow synthesis of 4, 5-disubstituted oxazoles

M Baumann, IR Baxendale, SV Ley, CD Smith…

Index: Baumann, Marcus; Baxendale, Ian R.; Ley, Steven V.; Smith, Christoper D.; Tranmer, Geoffrey K. Organic Letters, 2006 , vol. 8, # 23 p. 5231 - 5234

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Citation Number: 106

Abstract

A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured to provide the maximum flexibility for screening of reaction parameters that incorporate on-chip mixing and columns of solid supported reagents to expedite the chemical syntheses.