Synlett

A Convenient Method for the N-Acylation and Esterification of Hindered Amino Acids: Synthesis of Ultra Short Acting Opioid Agonist, Remifentanil

…, MD Goodyear, DWS Latham, AJ Whitehead

Index: Coleman, Mark J.; Goodyear, Michael D.; Latham, David W. S.; Whitehead, Andrew J. Synlett, 1999 , # 12 p. 1923 - 1924

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Citation Number: 5

Abstract

Abstract: A general method has been devised for the one step preparation of N-acylamino acid esters of type 7 from the corresponding a-amino acids in high yield under mild conditions and a probable mechanism is proposed. Key words: acylation, esterification, amino acids