Synlett

A convenient synthesis of chiral β3-amino acids

TK Chakraborty, A Ghosh

Index: Chakraborty, Tushar K.; Ghosh, Animesh Synlett, 2002 , # 12 p. 2039 - 2040

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Citation Number: 8

Abstract

Abstract A novel method for the synthesis of chiral β 3-amino acids is developed where the acid functionality was built by oxidative cleavage of an α-allylic group that was introduced by Evans' asymmetric alkylation of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction.

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