Asymmetric hydrogenation of alkenyl, cyclopropyl, and aryl ketones. RuCl2 (xylbinap)(1, 2-diamine) as a precatalyst exhibiting a wide scope

T Ohkuma, M Koizumi, H Doucet, T Pham…

Index: Ohkuma; Koizumi; Doucet; Pham; Kozawa; Murata; Katayama; Yokozawa; Ikariya; Noyori Journal of the American Chemical Society, 1998 , vol. 120, # 51 p. 13529 - 13530

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Citation Number: 372

Abstract

trans-RuCl2 (phosphine) 2 (1, 2-diamine), when coupled with a strong base in 2-propanol, acts as the most reactive catalyst for homogeneous hydrogenation of ketones. 1 Use of a chiral diphosphine and diamine ligand allows a rapid, productive, and enantioselective hydrogenation of simple ketones having no second heteroatom functionality. The asymmetric hydrogenation of certain aromatic ketones has achieved a TON (mols of ...

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